Every season new anti-aging products are launched and promoted as the new generation of slow aging. The question is “how do we know it works”? The gold standard of proof is a human clinical trial showing evidence of skin improvement however most topical ingredients have very limited research to back them up. This article looks at 4 ingredients that are commonly used in “anti-aging” products, the research that supports them and how to use them to greatest effect.

Vitamin C – Vitamin C has numerous slow aging

benefits: it works within the skin to promote collagen production by stimulating the genes that make collagen and stopping the enzyme that degrades it, it is an antioxidant and so reduces free-radical production in the skin, it also provides photoprotection from ultraviolet A and B, works to lighten hyperpigmentation and may also assist with the reduction of inflammation in inflammatory skin disorders.

Some great benefits however vitamin C is highly unstable in its natural form ascorbic acid and so it is advisable to only use stabilised forms such as magnesium ascorbyl phosphate or ascorbyl palmitate. Even so, vitamin C in these forms must be kept away from direct sunlight and used once opened otherwise they are prone to oxidation and stop being effective.

In addition, vitamin C absorbs into the skin very slowly and so higher concentrations are required for the above benefits. Look for products that contain 10-20% vitamin C as any less will not be effective. They also need to be acidic in form which is one of the factors that promotes an added exfoliation effect. Buffered vitamin C forms are less effective so make sur that your product has a pH of less than 3.8. If the pH and vitamin C concentration are not supplied with the product, ask your supplier before purchase to ensure you get the desired effects.

Alpha Hydroxy Acids - AHAs/PHAs will help slow aging by revitalising the topmost layer of skin. This effect is achieved by AHAs clearing dead skin cells, thinning the strata corneum thereby exposing newer skin cells, improving the quality of elastic fibres, increasing the density of collagen and stimulating the production of collagen. The net result is an anti-wrinkle effect and a reduction in signs of photoaging.

Most over the counter AHA products contain concentrations of 8-15% which promote visible results over time. However, concentrations lower than 8% do not show significant benefit and products such as cleansers and everyday moisturisers that list AHAs are unlikely to contain enough to make a significant difference.

Apple Skins contain natural fruit AHAs

The anti-wrinkle effect of AHAs is achieved by removing the top layer of dead skin cells (stratum corneum) however it also removes valuable antioxidants, particularly vitamin C and E and may also increases sun sensitivity. These side effects need to be countered by using sunscreen during the day and applying an antioxidant rich moisturiser following use of AHAs.

Due to their acidic nature AHA’s produce a tingling sensation on the skin. This effect is a sign that the product is working to exfoliate the top layers of skin. The exfoliation is gradual and results can be expected after 3 months of use. However, ongoing use of AHAs may have a mild dehydrating effect on the skin due to the potential for water loss as the strata corneum is thinned. To counter this effect, use AHAs for 2-3 months then take a break of 2-3 months.

Copper Peptides – Copper peptides emerged as a skin treatment product in the 70s when it was found to significantly stimulate skin wound healing. This end is achieved by promoting normal collagen growth rather than the abnormal collagen growth found in scar tissue. While these results were achieved with wound healing more recent use has shown that copper peptides may also have a collagen regenerating effect on normal skin. In particular, they can help repair skin after exfoliation (seen as controlled skin damage), minimise the daily assaults from sun damage and pollution and reduce skin inflammation which is significantly associated with hastening the aging process.

While copper peptides have a good safety and efficacy profile, there are some notes of caution related to using copper peptides. Again, with copper peptides, as with AHA’s more is not always better. Taking a break after 2-3 months is advisable as too much copper can have an irritating and pro-oxidant effect. In addition copper peptides are made less effective in an acidic environment so it is best to use them away from AHAs, vitamin C and retanoids.

Plant antioxidants – The most common significant finding for antioxidants of plant origin such as the catechins present in green tea, curcumin from the curry spice turmeric and apigenin present in many fruits and vegetables, is

Green Tea can reduce skin erythema

that they reduce the effects of UV damage in the skin.

For example studies using 10% green tea extract have shown that it works to minimise sun damage by reducing the production of free radicals and inflammation that result from exposure to UV rays. Apart from free radical damage, inflammation is a potential driver of premature skin ageing. Green tea would therefore be a useful addition to a sunscreen or daily moisturiser as it will provide an additional protective effective aside from the SPF factor. Please keep in mind, green tea is in no way a substitute for SPF rather it works by supporting the skins resistance to sun damage.

The unknown factor associated with the use of polyphenols and many other new topical ingredients is that unless a human clinical trial has been conducted, the concentration of the active ingredient required in the cream is unknown. Adding minute amounts of an extract to make a label claim may be beneficial from a marketing perspective but it doesn’t promote skin rejuvenation or slow skin aging.

When choosing a slow aging product for your skin, ensure that you choose those with a high enough concentration of the active ingredient where it is known and otherwise, that it is in at least the top 2/3 of the ingredient listing. Ingredients in the last 1/3 of the label listing are included in very small quantities. Alternatively, if an ingredient is touted as the active in a product then the concentration may be listed on the label. If in doubt, ask the retailer or manufacturer for this information.